Triethylamine → (E)-3-{3-Benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-phenyl}-N-isopropylacrylamide

Participants

Reaction Conditions

Reaction Steps

To a mixture of 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one (240 mg, 0.44 mmol), N-isopropylacrylamide (60 mg, 0.53 mmol) and triethylamine (445 mg, 0.44 mmol) in MeCN (5 mL) in a pressure vessel is added Pd(OAc)2 (5 mg) and the mixture is heated at 100° C. for 8 h. The solvent is removed under reduced pressure and the residue is purified by flash chromatography using hexane/EtOAc (86:15) as eluent to give the title compound as a solid.

Provenance & Evidence