HCID 68839260, compound → HCID 57777453, compound

HRID 660623Notes

Reaction equation

HRID 660623 reaction equation
C([O:8][C:9]1[CH:10]=[C:11](/[CH:23]=[CH:24]/[C:25]([OH:27])=O)[CH:12]=[CH:13][C:14]=1[N:15]1[CH2:19][C:18](=[O:20])[NH:17][S:16]1(=[O:22])=[O:21])C1C=CC=CC=1.[NH2:28][CH2:29][CH2:30][CH2:31][CH2:32][O:33][C:34]1[CH:41]=[CH:40][CH:39]=[C:38]([O:42]CC2C=CC=CC=2)[C:35]=1[C:36]#[N:37]>>[C:36]([C:35]1[C:38]([OH:42])=[CH:39][CH:40]=[CH:41][C:34]=1[O:33][CH2:32][CH2:31][CH2:30][CH2:29][NH:28][C:25](=[O:27])[CH2:24][CH2:23][C:11]1[CH:12]=[CH:13][C:14]([N:15]2[CH2:19][C:18](=[O:20])[NH:17][S:16]2(=[O:21])=[O:22])=[C:9]([OH:8])[CH:10]=1)#[N:37]

Participants

3

Reactant 2

HCID 68839260HCID 68839260, compoundHCID 68839439HCID 68839439, compound

Product 1

HCID 57777453HCID 57777453, compound

Procedure

The title compound is prepared using (E)-3-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-acrylic acid and 2-(4-aminobutoxy)-6-benzyloxybenzonitrile analogous to Example 100 steps C and D: (M−1)−=487. HPLC retention time: 0.82 min. (Method A).

Sources & evidence

ORD record
ord-5e3ee9b00288452082d3bb8dc34a397e
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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