反应详情

To a solution of (E)-2-acetylamino-3-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-acrylic acid methyl ester is added 3 equivalents of NaOH (3N solution). After 4 h, three additional equivalents of NaOH is added and stirring is continued for 18 h. The solvent is removed under reduced pressure and the residue acidified with 1N HCl and the mixture is extracted with EtOAc. The organic phase is washed with water and brine then is dried over sodium sulfate. The solvent is removed under reduced pressure to give the title compound. This is used directly in the next step.

1. waitis continued for 18 h
2. customThe solvent is removed under reduced pressure
3. extractionthe mixture is extracted with EtOAc
4. washThe organic phase is washed with water and brine
5. dry with materialthen is dried over sodium sulfate
6. customThe solvent is removed under reduced pressure