Hydrochloric Acid → 1-Benzenesulfonyl-2-vinylpyrrolidine

Participants

Reaction Conditions

Reaction Steps

To a suspension of methyl triphenylphosphonium bromide (357 mg, 1 mmol) in THF (10 mL) at −78° C. is added dropwise KHMDS (1 mmol, 2 mL of 0.5M solution). To this yellow solution is added dropwise a solution of 1-benzenesulfonylpyrrolidine-2-carbaldehyde (235 mg, 1 mmol) in THF (1 mL). The mixture is stirred at −78° C. for 2 h then is allowed to warm to RT. The mixture is poured into 1N HCl and extracted with EtOAc. The organic phase is washed with brine and dried over magnesium sulfate then the solvent removed under reduced pressure. The resulting oil is purified by flash chromatography using a gradient of 0-20% EtOAc/hexane as eluent to give the title compound.

Provenance & Evidence