Benzenesulfonyl chloride → HCID 68997018, compound

HRID 660658Notes

Reaction equation

[CH2:1]([O:8][C:9]1[CH:14]=[C:13](/[CH:15]=[CH:16]/[CH:17]2[CH2:21][CH2:20][NH:19][CH2:18]2)[CH:12]=[CH:11][C:10]=1[N:22]1[S:26](=[O:28])(=[O:27])[N:25]([CH2:29][CH2:30][Si:31]([CH3:34])([CH3:33])[CH3:32])[C:24](=[O:35])[CH2:23]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:36]1([S:42](Cl)(=[O:44])=[O:43])[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>>[C:36]1([S:42]([N:19]2[CH2:20][CH2:21][CH:17](/[CH:16]=[CH:15]/[C:13]3[CH:12]=[CH:11][C:10]([N:22]4[S:26](=[O:27])(=[O:28])[N:25]([CH2:29][CH2:30][Si:31]([CH3:33])([CH3:32])[CH3:34])[C:24](=[O:35])[CH2:23]4)=[C:9]([O:8][CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)[CH:14]=3)[CH2:18]2)(=[O:44])=[O:43])[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1

Participants

Reactant 2

HCID 7369Benzenesulfonyl chloride

HCID 68838281HCID 68838281, compound

Product 1

HCID 68997018HCID 68997018, compound

Procedure

The title compound is prepared from 5-[2-benzyloxy-4-((E)-2-pyrrolidin-3-yl-vinyl)-phenyl]-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one and benzenesulfonyl chloride analogous to Example 192, step B.

Sources & evidence

ORD record: ord-3949152d730344dfb9eee415641fc4cf
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08084448B2

Reaction notes

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