Trifluoroacetic acid → 5-{2-Benzyloxy-4-[(E)-(S)-2-(1,2,3,4-tetrahydroisoquinolin-3-yl)-vinyl]-phenyl}-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one

Participants

Reaction Steps

To a solution of (S)-3-((E)-2-{3-benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-phenyl}-vinyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester (0.22 g, 0.32 mmol) in CH2Cl2 (8 mL) is added TFA (3 mL). After stirring at RT for 1.5 h, the mixture is concentrated under reduced pressure to give the title compound which is used directly in the next step.

Provenance & Evidence