5-{2-Benzyloxy-4-[(E)-2-((S)-2-methanesulfonyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-vinyl]-phenyl}-1,1-dioxo-1,2,5-thiadiazolidin-3-one → 5-{2-Hydroxy-4-[2-((R)-2-methanesulfonyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-ethyl]-phenyl}-1,1-dioxo-1,2,5-thiadiazolidin-3-one

Participants

Reaction Steps

To a solution of 5-{2-benzyloxy-4-[(E)-2-((S)-2-methanesulfonyl-1,2,3,4-tetrahydroisoquinolin-3-yl)-vinyl]-phenyl}-1,1-dioxo-1,2,5-thiadiazolidin-3-one (0.090 g, 0.16 mmol) in EtOH (4 mL) is added a slurry of 10% Pd/C (0.1 g) in EtOH (6 mL). The reaction vessel is flushed twice with H2 and stirred at RT for 18 h under balloon pressure of H2. The mixture is filtered and purified by reverse phase chromatography using a gradient of 15 to 40% EtOH/water to afford the title compound as a white solid: LC retention time=1.0 min (Method A); (M+NH4)+=465.

Provenance & Evidence