HRID660667

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7369

Benzenesulfonyl chloride

C6H5ClO2S

结构：C[Si](C)(C)CCN1C(=O)CN(c2ccc(/C=C/[C@@H]3Cc4ccccc4CN3)cc2OCc2ccccc2)S1(=O)=O

HCID68839683

未命名化合物

PRODUCTS

生成物

结构：O=C1CN(c2ccc(CC[C@@H]3Cc4ccccc4CN3S(=O)(=O)c3ccccc3)cc2O)S(=O)(=O)N1

HCID57777466

未命名化合物

PROCEDURE

实验过程

The title compound is prepared from 5-{2-benzyloxy-4-[(E)-(S)-2-(1,2,3,4-tetrahydroisoquinolin-3-yl)-vinyl]-phenyl}-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one and benzenesulfonyl chloride analogous to Example 200, steps F, G and H: LC retention time=1.26 min (Method A); (M+NH4)+=545.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4981bd6809324b98ac43ea86c6254252
来源数据集: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08084448B2
来源说明: uspto-grants-2011_12

反应 SMILES

C([O:8][C:9]1[CH:14]=[C:13](/[CH:15]=[CH:16]/[C@@H:17]2[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][NH:18]2)[CH:12]=[CH:11][C:10]=1[N:27]1[S:31](=[O:33])(=[O:32])[N:30](CC[Si](C)(C)C)[C:29](=[O:40])[CH2:28]1)C1C=CC=CC=1.[C:41]1([S:47](Cl)(=[O:49])=[O:48])[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1>>[C:41]1([S:47]([N:18]2[C@H:17]([CH2:16][CH2:15][C:13]3[CH:12]=[CH:11][C:10]([N:27]4[S:31](=[O:33])(=[O:32])[NH:30][C:29](=[O:40])[CH2:28]4)=[C:9]([OH:8])[CH:14]=3)[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19]2)(=[O:49])=[O:48])[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1