4-(Trifluoromethyl)benzenesulfonyl chloride → HCID 57777441, compound

HRID 660668Notes

Reaction equation

HRID 660668 reaction equation
C([O:8][C:9]1[CH:14]=[C:13](/[CH:15]=[CH:16]/[CH:17]2[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][NH:18]2)[CH:12]=[CH:11][C:10]=1[N:27]1[S:31](=[O:33])(=[O:32])[N:30](CC[Si](C)(C)C)[C:29](=[O:40])[CH2:28]1)C1C=CC=CC=1.[F:41][C:42]([F:54])([F:53])[C:43]1[CH:48]=[CH:47][C:46]([S:49](Cl)(=[O:51])=[O:50])=[CH:45][CH:44]=1>>[OH:8][C:9]1[CH:14]=[C:13]([CH2:15][CH2:16][CH:17]2[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][N:18]2[S:49]([C:46]2[CH:45]=[CH:44][C:43]([C:42]([F:41])([F:53])[F:54])=[CH:48][CH:47]=2)(=[O:51])=[O:50])[CH:12]=[CH:11][C:10]=1[N:27]1[S:31](=[O:33])(=[O:32])[NH:30][C:29](=[O:40])[CH2:28]1

Participants

3

Reactant 2

HCID 27773994-(Trifluoromethyl)benzenesulfonyl chlorideHCID 68994521HCID 68994521, compound

Product 1

HCID 57777441HCID 57777441, compound

Procedure

The title compound is prepared from 5-{2-benzyloxy-4-[(E)-2-(1,2,3,4-tetrahydroisoquinolin-3-yl)-vinyl]-phenyl}-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one and 4-trifluoromethylbenzenesulfonyl chloride analogous to Example 200, steps F, G and H: (M−1)−=546.

Sources & evidence

ORD record
ord-69922ff543054618b057141f2a908e46
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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