Phenylmethanesulfonyl chloride → HCID 57777390, compound

HRID 660669Notes

Reaction equation

C([O:8][C:9]1[CH:14]=[C:13](/[CH:15]=[CH:16]/[CH:17]2[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][NH:18]2)[CH:12]=[CH:11][C:10]=1[N:27]1[S:31](=[O:33])(=[O:32])[N:30](CC[Si](C)(C)C)[C:29](=[O:40])[CH2:28]1)C1C=CC=CC=1.[CH2:41]([S:48](Cl)(=[O:50])=[O:49])[C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1>>[OH:8][C:9]1[CH:14]=[C:13]([CH2:15][CH2:16][CH:17]2[CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH2:19][N:18]2[S:48]([CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)(=[O:50])=[O:49])[CH:12]=[CH:11][C:10]=1[N:27]1[S:31](=[O:33])(=[O:32])[NH:30][C:29](=[O:40])[CH2:28]1

Participants

Reactant 2

HCID 74740Phenylmethanesulfonyl chloride

HCID 68994521HCID 68994521, compound

Product 1

HCID 57777390HCID 57777390, compound

Procedure

The title compound is prepared from 5-{2-benzyloxy-4-[(E)-2-(1,2,3,4-tetrahydroisoquinolin-3-yl)-vinyl]-phenyl}-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one and benzylsulfonyl chloride analogous to Example 200, steps F, G and H: (M−1)−=492.

Sources & evidence

ORD record: ord-7b0f11b2b7da41d99c3b2b4df2d6ce27
Source dataset: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08084448B2

Reaction notes

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