HRID660677

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)OC(=O)[C@H](Cc1ccc(N2CC(=O)N(CC[Si](C)(C)C)S2(=O)=O)c(OCc2ccccc2)c1)NS(=O)(=O)c1ccccc1

HCID68842899

未命名化合物

PRODUCTS

生成物

结构：C[Si](C)(C)CCN1C(=O)CN(c2ccc(C[C@H](NS(=O)(=O)c3ccccc3)C(=O)O)cc2OCc2ccccc2)S1(=O)=O

HCID68838051

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID21863450

未命名化合物

PROCEDURE

实验过程

A solution of (S)-2-benzenesulfonylamino-3-{3-benzyloxy-4-[1,1,4-trioxo-5-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-2-yl]-phenyl}-propionic acid tert-butyl ester (80 mg, 0.114 mmol) in 12 mL of TFA/CH2Cl2 (5:1) is stirred at RT for 1 h. The solution is concentrated, then four times redissolved in CH2Cl2 and reconcentrated to give the title compound: (M−1)−=644.

WORKUP

后处理

concentrationThe solution is concentrated
dissolutionfour times redissolved in CH2Cl2

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cc0e21d06e834e55846ba6b36bcac439
来源数据集: uspto-grants-2011_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08084448B2
来源说明: uspto-grants-2011_12

反应 SMILES

C([O:5][C:6](=[O:47])[C@@H:7]([NH:37][S:38]([C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)(=[O:40])=[O:39])[CH2:8][C:9]1[CH:14]=[CH:13][C:12]([N:15]2[CH2:19][C:18](=[O:20])[N:17]([CH2:21][CH2:22][Si:23]([CH3:26])([CH3:25])[CH3:24])[S:16]2(=[O:28])=[O:27])=[C:11]([O:29][CH2:30][C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)[CH:10]=1)(C)(C)C>C(O)(C(F)(F)F)=O.C(Cl)Cl>[C:41]1([S:38]([NH:37][C@@H:7]([CH2:8][C:9]2[CH:14]=[CH:13][C:12]([N:15]3[CH2:19][C:18](=[O:20])[N:17]([CH2:21][CH2:22][Si:23]([CH3:25])([CH3:26])[CH3:24])[S:16]3(=[O:28])=[O:27])=[C:11]([O:29][CH2:30][C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)[CH:10]=2)[C:6]([OH:47])=[O:5])(=[O:40])=[O:39])[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1