Boron tribromide → HCID 57777336, compound

Participants

Reaction Steps

To a solution of 5-{2-benzyloxy-4-[3-(1,1-dioxotetrahydrothiophen-2-yl)-prop-1-ynyl]-phenyl}-1,1-dioxo-1,2,5-thiadiazolidin-3-one in methylene chloride (5 mL) is added BBr3 (0.35 mL of 1.0 M in methylene chloride) and the mixture is stirred at RT for 18 h. The solvent is removed under reduced pressure and the residue purified by preparative HPLC followed by lyophilization to give the title compound: (M−1)−=383; HPLC retention time=0.72 min. (Method A)

Provenance & Evidence