HCID 69001892, compound → HCID 57777439, compound

Participants

Reaction Steps

To a solution of 5-[2-benzyloxy-4-(2-methyl-3-oxo-pentyl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one potassium salt in 5 mL of EtOH/water (1:1)) is added 20 mg of Degussa Pd/C and the resulting mixture is hydrogenated at 1 atm for 30 min. The catalyst is filtered through Celite and the solvent is removed under reduced pressure. The residue is purified by preparative HPLC to give the title compound: 1H NMR (Acetonitrile-d3) δ 7.30 (d, J=8.0 Hz, 1H), 6.79 (m, 1H), 6.75 (dd, J=8.0, 2.0 Hz, 1H), 4.38 (s, 2H), 2.83 (m, 2H), 2.46 (m, 2H), 2.29 (m, 1H), 1.01 (m, 3H), 0.9 (t, J=7.33 Hz, 3H). (M−1)−=325. HPLC retention time=0.92 min (Method A).

Provenance & Evidence