HCID 68843800, compound → HCID 57777347, compound

HRID 660704Notes

Reaction equation

HRID 660704 reaction equation
[K].[C:2]([CH:10]([CH2:34][CH3:35])[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[S:22](=[O:24])(=[O:23])[NH:21][C:20](=[O:25])[CH2:19]2)=[C:14]([O:26]CC2C=CC=CC=2)[CH:13]=1)(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>CCO.O.[Pd]>[C:2]([CH:10]([CH2:34][CH3:35])[CH2:11][C:12]1[CH:17]=[CH:16][C:15]([N:18]2[S:22](=[O:24])(=[O:23])[NH:21][C:20](=[O:25])[CH2:19]2)=[C:14]([OH:26])[CH:13]=1)(=[O:9])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 1

HCID 68843800HCID 68843800, compound

Product 1

HCID 57777347HCID 57777347, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 19096565Water ethanolSolvent

Procedure

A solution of 5-[4-(2-benzoylbutyl)-2-benzyloxyphenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one potassium salt (45 mg) in 4 mL of EtOH/water (1:1) is hydrogenated over Degussa 5% Pd/C (7 mg) at 1 atm for 6 h. The catalyst is filtered and the solvent is removed under reduced pressure to give the title compound: (M−1)−=387. HPLC retention time=0.60 min (Method C).

Workup

  1. filtrationThe catalyst is filtered
  2. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-aca437d3f22c4f8d86db0dfdb4a752d7
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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