HCID 68838962, compound → HCID 57777409, compound

Participants

Reaction Steps

A mixture of 5-[4-(2-benzyl-3-oxo-3-phenylpropyl)-2-benzyloxyphenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one (40 mg, 0.069 mmol) and 7 mg of Degussa 5% Pd/C in 4 mL of ethanol/water (1:1) is hydrogenated at 1 atm for 8 h at RT. The catalyst is filtered through Celite, washed with 1:1 ethanol/water and the filtrate concentrated under reduced pressure. The resulting residue is stripped four times with ethanol and the resulting solid is triturated with ether and dried to afford the title compound as a solid: (M−1)−=449. HPLC retention time=0.88 min (Method C).

Provenance & Evidence