1,1,1-Trifluoro-2-phenylbut-3-en-2-ol → HCID 57777450, compound

HRID 660717Notes

Reaction equation

HRID 660717 reaction equation
C([O:8][C:9]1[CH:14]=[C:13](I)[CH:12]=[CH:11][C:10]=1[N:16]1[S:20](=[O:22])(=[O:21])[NH:19][C:18](=[O:23])[CH2:17]1)C1C=CC=CC=1.[F:24][C:25]([F:37])([F:36])[C:26]([C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)([OH:29])[CH:27]=[CH2:28]>>[OH:8][C:9]1[CH:14]=[C:13]([CH2:28][CH2:27][C:26]([OH:29])([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[C:25]([F:24])([F:36])[F:37])[CH:12]=[CH:11][C:10]=1[N:16]1[S:20](=[O:21])(=[O:22])[NH:19][C:18](=[O:23])[CH2:17]1

Participants

3

Reactant 2

HCID 27345761,1,1-Trifluoro-2-phenylbut-3-en-2-olHCID 688386435-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one

Product 1

HCID 57777450HCID 57777450, compound

Procedure

The title compound is prepared from 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one and 1,1,1-trifluoro-2-phenyl-but-3-en-2-ol analogous to Example 44: (M−1)−=429; HPLC retention time=1.29 min (method A).

Sources & evidence

ORD record
ord-8235efdc619548ee84bcc1984cacb5c5
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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