Sodium Carbonate → 5-(3-Benzyloxybiphenyl-4-yl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one

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Reaction Conditions

Reaction Steps

A mixture of 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (200 mg, 0.45 mmol), phenylboronic acid (180 mg, 0.83 mmol), Pd(PPh3)4 (100 mg, 20 mol %) and aqueous Na2CO3 (0.83 mL of a 2M solution) in DME (3 mL) is placed in a microwave vial and heated at 110° C. for 15 min. The mixture is filtered, diluted with EtOAc and washed with 1N HCl. The organic phase is dried over magnesium sulfate and the solvent removed under reduced pressure to give the title compound which is used directly in the next step.

Provenance & Evidence