Thiophene-3-boronic acid → HCID 57777448, compound

HRID 660720Notes

Reaction equation

HRID 660720 reaction equation
C([O:8][C:9]1[CH:14]=[C:13](I)[CH:12]=[CH:11][C:10]=1[N:16]1[S:20](=[O:22])(=[O:21])[NH:19][C:18](=[O:23])[CH2:17]1)C1C=CC=CC=1.[S:24]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25]1>>[OH:8][C:9]1[CH:14]=[C:13]([C:26]2[CH:27]=[CH:28][S:24][CH:25]=2)[CH:12]=[CH:11][C:10]=1[N:16]1[S:20](=[O:21])(=[O:22])[NH:19][C:18](=[O:23])[CH2:17]1

Participants

3

Reactant 2

HCID 581760Thiophene-3-boronic acidHCID 688386435-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one

Product 1

HCID 57777448HCID 57777448, compound

Procedure

The title compound is prepared using 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one and thiophene-3-boronic acid analogous to Example 272: 1H NMR (DMSO-d6δ9.68 (br s, 1H), 7.75 (m, 1H), 7.61 (m, 1H), 7.43 (m, 1H), 7.38 (m, 1H), 7.15 (m, 2H), 4.32 (s, 2H); (M−1)−=309.

Sources & evidence

ORD record
ord-6dca854d4094493d8f2220dba4bb09e7
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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