6-Methoxy-2,3-dihydro-1-benzofuran-3-one → 5-[2-Hydroxy-4-(6-methoxybenzofuran-3-yl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one

HRID 660723Notes

Reaction equation

HRID 660723 reaction equation
C([O:8][C:9]1[CH:14]=[C:13](I)[CH:12]=[CH:11][C:10]=1[N:16]1[S:20](=[O:22])(=[O:21])[NH:19][C:18](=[O:23])[CH2:17]1)C1C=CC=CC=1.[CH3:24][O:25][C:26]1[CH:35]=[CH:34][C:29]2[C:30](=O)[CH2:31][O:32][C:28]=2[CH:27]=1>>[OH:8][C:9]1[CH:14]=[C:13]([C:30]2[C:29]3[CH:34]=[CH:35][C:26]([O:25][CH3:24])=[CH:27][C:28]=3[O:32][CH:31]=2)[CH:12]=[CH:11][C:10]=1[N:16]1[S:20](=[O:21])(=[O:22])[NH:19][C:18](=[O:23])[CH2:17]1

Participants

3

Reactant 2

HCID 5853686-Methoxy-2,3-dihydro-1-benzofuran-3-oneHCID 688386435-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one

Product 1

HCID 577773095-[2-Hydroxy-4-(6-methoxybenzofuran-3-yl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one

Procedure

The title compound is prepared from 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one and 6-methoxybenzofuran-3-one analogous to Example 274: (M−1)−=373; HPLC retention time=1.09 min. (Method A).

Sources & evidence

ORD record
ord-fc4b535b8b08453488610ead217b959f
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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