反应详情

To a solution of 5-(2-benzyloxy-4-thiazol-5-yl-phenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (87 mg, 0.217 mmol) in EtOH (2.5 mL) and water (22.5 mL) is added 10% Pd/C (100 mg) and the mixture is stirred under an atmosphere of H2 for 2.5 h. The mixture is filtered through Celite and the filtrate evaporated. The residue is purified by reverse phase HPLC (CH3CN/water/0.1% TFA) to afford the title compound as a light yellow solid: 1H NMR (CD3O4.37 (s, 1H), 7.04 (d, J=8 Hz, 1H), 7.08 (s, 1H), 7.35 (d, J=8 Hz, 1H), 7.97 (s, 1H), 8.79 (s, 1H); (M−1)−=310.

1. filtrationThe mixture is filtered through Celite
2. customthe filtrate evaporated
3. customThe residue is purified by reverse phase HPLC (CH3CN/water/0.1% TFA)