Sodium Carbonate → HCID 68840366, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (100 mg, 0.225 mmol), 4-pyrazoleboronic acid (87 mg, 0.45 mmol), resin-bound PPh3Pd (346 mg, loading 0.13 mmol/g) and aqueous Na2CO3 (0.45 mL of a 2M solution) in DME (3 mL) is heated in a microwave apparatus at 110° C. for 30 min. The mixture is filtered and the solvent removed under reduced pressure. The residue is purified by reverse phase MPLC to give the title compound.

Provenance & Evidence