Sodium Hydroxide → HCID 68839757, compound

HRID 660747Notes

Reaction equation

HRID 660747 reaction equation
[C:1]1([CH2:7][S:8]([CH2:11][CH2:12][CH2:13][CH2:14][O:15]C(=O)C)(=[O:10])=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[C:1]1([CH2:7][S:8]([CH2:11][CH2:12][CH2:13][CH2:14][OH:15])(=[O:9])=[O:10])[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68839695HCID 68839695, compound

Product 1

HCID 68839757HCID 68839757, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of acetic acid 4-phenylmethanesulfonylbutyl ester (1.6 g, 5.93 mmol) in MeOH (20 mL) is added NaOH (6.0 ml of 1.0N) and the mixture is stirred at RT for 90 min. The MeOH is removed under reduced pressure and the aqueous extracted with EtOAc. The organic solution is dried over magnesium sulfate and the solvent is removed under reduced pressure. The resulting solid is triturated with hexane to give the title compound as a white solid.

Workup

  1. customThe MeOH is removed under reduced pressure
  2. extractionthe aqueous extracted with EtOAc
  3. dry with materialThe organic solution is dried over magnesium sulfate
  4. customthe solvent is removed under reduced pressure
  5. customThe resulting solid is triturated with hexane

Sources & evidence

ORD record
ord-65d9c58fc64f49fa980b124ea89aab9c
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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