Water → HCID 57777330, compound

Participants

Reaction Steps

A mixture of 5-[2-benzyloxy-4-(4-phenylmethanesulfonylbutyl)-phenyl]-1,1-dioxo-1,2,5-thiadiazolidin-3-one (450 mg), 10% Pd/C (400 mg) and KHCO3 (1.6 mL of 0.52M) in EtOH (1 mL)/water (10 mL) is hydrogenated at 1 atm for 2 h. The catalyst is filtered and the filtrate evaporated. The residue is treated with 1N HCl and extracted with EtOAc. The organic phase is dried over magnesium sulfate and the solvent removed under reduced pressure to give the title compound: (M−1)−=347 1H NMR (400 MHz, DMSO-D6) δ ppm 1.38-1.48 (m, 2 H) 1.49-1.58 (m, J=7.67, 7.67, 7.52, 7.20 Hz, 3 H) 1.79-1.85 (m, 2 H) 2.43 (t, J=7.45 Hz, 2 H) 4.01 (s, 2 H) 6.56 (dd, J=8.08, 1.77 Hz, 1 H) 6.67 (d, J=1.77 Hz, 1 H) 7.25 (d, J=8.08 Hz, 1 H)

Provenance & Evidence