HCID 68838563, compound → HCID 57777378, compound

HRID 660753Notes

Reaction equation

HRID 660753 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH2:23][CH2:24][CH2:25][C:26]#[N:27])[CH:12]=[CH:13][C:14]=1[N:15]1[CH2:19][C:18](=[O:20])[NH:17][S:16]1(=[O:22])=[O:21])C1C=CC=CC=1>C(O)C.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH2:23][CH2:24][CH2:25][C:26]#[N:27])[CH:12]=[CH:13][C:14]=1[N:15]1[CH2:19][C:18](=[O:20])[NH:17][S:16]1(=[O:22])=[O:21]

Participants

4

Reactant 1

HCID 68838563HCID 68838563, compound

Product 1

HCID 57777378HCID 57777378, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of 4-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenyl]-butyronitrile (30 mg) in ethanol (30 mL) is hydrogenated over 10% Pd/C at 1 atm for 1 h. The catalyst is removed by filtration through Celite and the solvent is removed under reduced pressure to give the title compound. It is converted to a potassium salt by addition of 1 equivalent of KHCO3: (M−1)−=294.

Workup

  1. customThe catalyst is removed by filtration through Celite
  2. customthe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-bf0e00459ff74eec8a7c1277f1e2bbe6
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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