Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 1,3-Bis(tosyloxy)-2,2-dimethylpropane | HCID 264253 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | HCID 323833 | HCID 323833 | — |
Reaction Steps
To a solution of toluene-4-sulfonic acid 3-toluene-4-sulfonyloxy-2,2-dimethylpropyl ester (5.0 g, 12.1 mmol) in DMSO (15 mL) is added KCN (789 mg, 12.1 mmol). The mixture is stirred at 80° C. for 18 h then cooled to RT. The mixture is poured into water and extracted with ether. The organic layer is dried over sodium sulfate the filtrate concentrated. The crude material is purified by column chromatography to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08084448B2 |
|---|
| Source dataset | uspto-grants-2011_12 |
|---|
| ORD ID | ord-23a048d5281142318617d81f4b51af15 |
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| Source note | uspto-grants-2011_12 |
|---|
