HCID 68997226, compound → Methyl N-(aminosulfonyl)-N-(2-(benzyloxy)-4-{2-oxo-2-[2-(trimethylsilyl)ethoxy]ethoxy}phenyl)glycinate

HRID 660764Notes

Reaction equation

HRID 660764 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[C:13]([O:15][CH2:16][C:17](=[O:25])[O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])[CH:12]=[CH:11][C:10]=1[N:26]([S:32]([NH:35]C(OC(C)(C)C)=O)(=[O:34])=[O:33])[CH2:27][C:28]([O:30][CH3:31])=[O:29])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Cl.O1CCOCC1>[NH2:35][S:32]([N:26]([C:10]1[CH:11]=[CH:12][C:13]([O:15][CH2:16][C:17](=[O:25])[O:18][CH2:19][CH2:20][Si:21]([CH3:24])([CH3:23])[CH3:22])=[CH:14][C:9]=1[O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[CH2:27][C:28]([O:30][CH3:31])=[O:29])(=[O:33])=[O:34]

Participants

3

Reactant 1

HCID 68997226HCID 68997226, compound

Product 1

HCID 68840538Methyl N-(aminosulfonyl)-N-(2-(benzyloxy)-4-{2-oxo-2-[2-(trimethylsilyl)ethoxy]ethoxy}phenyl)glycinate

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

A mixture of methyl N-(2-(benzyloxy)-4-{2-oxo-2-[2-(trimethylsilyl)ethoxy]ethoxy}phenyl)-N-{[(tert-butoxycarbonyl)amino]sulfonyl}glycinate (50 mg, 0.08 mmol) in HCl/dioxane (3 mL, 4.0 M) is stirred at RT for 30 min. The solvent is removed under reduced pressure and water is added. The mixture is extracted with EtOAc and the organic phase dried over magnesium sulfate. The solvent is removed under reduced pressure to give the title compound.

Workup

  1. customThe solvent is removed under reduced pressure and water
  2. additionis added
  3. extractionThe mixture is extracted with EtOAc
  4. dry with materialthe organic phase dried over magnesium sulfate
  5. customThe solvent is removed under reduced pressure

Sources & evidence

ORD record
ord-d4b869541ab64a34be7236b77e328d2d
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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