HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(3-Benzyloxy-4-nitrophenoxy)-1,3,4,5-tetrahydrobenzo[b]azepin-2-one → 3-(4-Amino-3-benzyloxyphenoxy)-1,3,4,5-tetrahydrobenzo[b]azepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(3-Benzyloxy-4-nitrophenoxy)-1,3,4,5-tetrahydrobenzo[b]azepin-2-one | HCID 68839552 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Solvent | Ethylacetate methanol | HCID 21584119 | — |
| Product | 3-(4-Amino-3-benzyloxyphenoxy)-1,3,4,5-tetrahydrobenzo[b]azepin-2-one | HCID 68839029 | — |
Reaction Steps
A solution of 3-(3-benzyloxy-4-nitrophenoxy)-1,3,4,5-tetrahydrobenzo[b]azepin-2-one (3.0 g, 7.4 mmol) in 50 mL EtOAc/MeOH (1:1) is hydrogenated at 1 atm over platinum oxide for 2.5 h. The catalyst is filtered and the filtrate evaporated to give the title compound which is used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08084448B2 |
| Source dataset | uspto-grants-2011_12 |
| ORD ID | ord-91d5b6f6a8314889bdcdd785769c4d22 |
| Source note | uspto-grants-2011_12 |