HCID 68843315, compound → HCID 57777270, compound

HRID 660771Notes

Reaction equation

HRID 660771 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH:25]=[CH:26][C:27]=1[N:28]1[CH2:32][C:31](=[O:33])[NH:30][S:29]1(=[O:35])=[O:34])[O:12][CH:13]1[C:19](=[O:20])[NH:18][C:17]2[CH:21]=[CH:22][CH:23]=[CH:24][C:16]=2[CH2:15][CH2:14]1)C1C=CC=CC=1>CCO.CC(O)=O.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH:25]=[CH:26][C:27]=1[N:28]1[CH2:32][C:31](=[O:33])[NH:30][S:29]1(=[O:34])=[O:35])[O:12][CH:13]1[C:19](=[O:20])[NH:18][C:17]2[CH:21]=[CH:22][CH:23]=[CH:24][C:16]=2[CH2:15][CH2:14]1

Participants

4

Reactant 1

HCID 68843315HCID 68843315, compound

Product 1

HCID 57777270HCID 57777270, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 18476134Acetic acid ethanolSolvent

Procedure

A solution of 3-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-phenoxy]-1,3,4,5-tetrahydro-benzo[b]azepin-2-one (244 mg) in 30 mL of EtOH/HOAc (2:1) is hydrogenated at 1 atm over Pd/C (100 mg) for 4 h. The catalyst is filtered and the filtrate evaporated. The residual solid is triturated with ether to give the title compound: (M−1)−=402.

Workup

  1. filtrationThe catalyst is filtered
  2. customthe filtrate evaporated
  3. customThe residual solid is triturated with ether

Sources & evidence

ORD record
ord-7302e433aae045439b5c1ae63ff7fdf4
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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