Water → 5-{2-Hydroxy-4-[1-(2,4,6-trimethylphenyl)-ethyl]-phenyl}-1,1-dioxo-1,2,5-thiadiazolidin-3-one

Participants

Reaction Steps

A solution of 5-{2-benzyloxy-4-[1-(2,4,6-trimethylphenyl)-ethyl]-phenyl}-1,1-dioxo-1,2,5-thiadiazolidin-3-one and K2CO3 (60 mg) in EtOH (5 mL)/water (7 mL) is hydrogenated at 1 atm over 10% Pd/C (50 mg) for 10 days. The catalyst is filtered and the solvent evaporated to give the title compound as a pale-yellow solid: (M−1)−=373. HPLC retention time: 1.45 min (Method A).

Provenance & Evidence