HCID 68842200, compound → HCID 57777470, compound

HRID 660794Notes

Reaction equation

HRID 660794 reaction equation
C([O:8][C:9]1[CH:10]=[C:11]([CH:21]=[CH:22][C:23]=1[N:24]1[CH2:28][C:27](=[O:29])[NH:26][S:25]1(=[O:31])=[O:30])[CH2:12][C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[C:15]#[N:16])C1C=CC=CC=1>CCO.O.[Pd]>[NH2:16][CH2:15][C:14]1[CH:17]=[CH:18][CH:19]=[CH:20][C:13]=1[CH2:12][C:11]1[CH:21]=[CH:22][C:23]([N:24]2[S:25](=[O:31])(=[O:30])[NH:26][C:27](=[O:29])[CH2:28]2)=[C:9]([OH:8])[CH:10]=1

Participants

4

Reactant 1

HCID 68842200HCID 68842200, compound

Product 1

HCID 57777470HCID 57777470, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 19096565Water ethanolSolvent

Procedure

A solution of 2-[3-benzyloxy-4-(1,1,4-trioxo-1,2,5-thiadiazolidin-2-yl)-benzyl]-benzonitrile in EtOH/water (1:1) is hydrogenated at 1 atm over 10% Pd/C for 40 min. The catalyst is filtered, the solvent evaporated and the residue purified by preparative HPLC to give the title compound.

Workup

  1. filtrationThe catalyst is filtered
  2. customthe solvent evaporated
  3. customthe residue purified by preparative HPLC

Sources & evidence

ORD record
ord-db52030bf3ee440296d30a80d4a44909
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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