5-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one → HCID 57777465, compound

HRID 660801Notes

Reaction equation

HRID 660801 reaction equation
C([O:8][C:9]1[CH:14]=[C:13](I)[CH:12]=[CH:11][C:10]=1[N:16]1[S:20](=[O:22])(=[O:21])[N:19](CC[Si](C)(C)C)[C:18](=[O:29])[CH2:17]1)C1C=CC=CC=1.I[CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[CH2:38][C:39]#[N:40]>>[OH:8][C:9]1[CH:14]=[C:13]([CH:12]=[CH:11][C:10]=1[N:16]1[CH2:17][C:18](=[O:29])[NH:19][S:20]1(=[O:21])=[O:22])[CH2:31][C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][C:33]=1[CH2:38][C:39]#[N:40]

Participants

3

Reactant 2

HCID 667569375-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-oneHCID 68838682HCID 68838682, compound

Product 1

HCID 57777465HCID 57777465, compound

Procedure

The title compound is prepared from 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-2-(2-trimethylsilanylethyl)-1,2,5-thiadiazolidin-3-one and (2-iodomethylphenyl)-acetonitrile analogous to Example 310, steps C, D and E. (M−1)−=356. HPLC retention time=0.93 min (Method A).

Sources & evidence

ORD record
ord-561e659116294a89810b8d2926a15cff
Source dataset
uspto-grants-2011_12
Patent number
US08084448B2

Reaction notes

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