HCID 68839874, compound → HCID 68838865, compound

Participants

Reaction Steps

A solution of N-(t-butoxycarbonylsulfamoyl)-N-(4-benzenesulfonyl-2-benzyloxyphenyl)glycine methyl ester (620 mg, 1.05 mmol) in 10 mL TFA/CH2Cl2 (1:1) is stirred at RT for 30 min. The solvent is removed under reduced pressure and the residue is redissolved in CH2Cl2 and restripped (4×). The residual oil is chromatographed on a Biotage 40M column using CH2Cl2/EtOAc (90:10) as eluent to afford the title compound: 1H NMR (CDCl3) δ 7.87 (m, 2H), 7.72 (d, J=8.2 Hz, 1H), 7.60 (m, 2H), 7.50 (m, 3H), 7.41 (m, 5H), 5.18 (s, 2H), 4.92 (br s, 2H), 4.32 (s, 2H), 3.87 (s, 3H); MS (M−1)−=489.

Provenance & Evidence