5-(2-Benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one → HCID 68843474, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-(2-benzyloxy-4-iodophenyl)-1,1-dioxo-1,2,5-thiadiazolidin-3-one (108.4 mg, 0.243 mmol) in DMF (2 mL) is added KHCO3 (0.488 mL, 0.5M aqueous solution), CuCN (19 mg, 0.212 mmol) and resin-bound PPh3Pd (10 mol %) in DMF (2 mL) and the mixture is heated in a microwave apparatus at 110° C. for 20 min. The solvent is removed under reduced pressure and the residue purified by reverse phase MPLC to give the title compound.

Provenance & Evidence