反应详情

A solution of [(2-benzyloxy-4-chlorophenyl)-tert-butoxycarbonylamino]-acetic acid methyl ester (14.95 g, 36.8 mmol) in 180 mL of TFA/methylene chloride (1:2) is stirred at RT for 45 min. The solvent is removed under reduced pressure and the residue is dissolved in EtOAc (500 mL). To this solution is added diisopropylethylamine (13.11 g) and the resulting precipitate is filtered. The filtrate is evaporated to give the title compound as a tan solid. (M+1)=306.

1. customThe solvent is removed under reduced pressure
2. dissolutionthe residue is dissolved in EtOAc (500 mL)
3. additionTo this solution is added diisopropylethylamine (13.11 g)
4. filtrationthe resulting precipitate is filtered
5. customThe filtrate is evaporated