Benzyl Bromide → 2-(Benzyloxy)-4-fluoro-1-nitrobenzene

Participants

Reaction Steps

To a stirred solution of 5-fluoro-2-nitrophenol (1.57 g, 10 mmol) and benzyl bromide (1.25 mL, 10.5 mmol) in DMF (20 mL) is added K2CO3 (2.07 g, 15 mmol) and the suspension is stirred at RT overnight. The reaction is quenched with water and the aqueous layer is extracted with EtOAc. The combined organic layers are washed with water and brine, then dried over MgSO4 and filtered. The solvent is removed under reduced pressure to give the product as a pale yellow solid.

Provenance & Evidence