Water → HCID 68839799, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-benzyloxy-1,5-difluoro-3-nitrobenzene (2.60 g, 9.80 mmol) in EtOH (20 mL)/water (10 mL) is added zinc (3.4 g, 49 mmol) and ammonium chloride (1.0 g, 19.6 mmol) and the mixture is heated at 60° C. for 2 h. The mixture is extracted with EtOAc and the solvent is removed under reduced pressure. The residue is dissolved in methylene chloride and the solution washed with water. The organic phase is dried over sodium sulfate. The solvent is removed under reduced pressure to give the title compound which is used directly to the next step without purification.

Provenance & Evidence