Diethyl Ether → 2-(4-chlorobenzoyl)-N-(3-fluorophenylmethyl)-hydrazinecarboxamide

HRID 660842노트

반응식

HRID 660842 반응식
[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH2:9])=[O:7])=[CH:4][CH:3]=1.[F:12][C:13]1[CH:14]=[C:15]([CH2:19][N:20]=[C:21]=[O:22])[CH:16]=[CH:17][CH:18]=1.C(OCC)C>O1CCCC1>[Cl:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([NH:8][NH:9][C:21]([NH:20][CH2:19][C:15]2[CH:16]=[CH:17][CH:18]=[C:13]([F:12])[CH:14]=2)=[O:22])=[O:7])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 108164-ChlorobenzohydrazideHCID 6434993-Fluorobenzyl isocyanate

생성물 1

HCID 580116772-(4-chlorobenzoyl)-N-(3-fluorophenylmethyl)-hydrazinecarboxamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

실험 절차

553 mg (3.24 mmol) of 4-chlorobenzoic acid hydrazide are placed in 10 ml tetrahydrofuran at room temperature. 500 mg (3.31 mmol) of 3-fluorophenylmethyl isocyanate, dissolved in 5 ml tetrahydrofuran, are rapidly added dropwise to this suspension with stirring. The mixture is further stirred overnight at room temperature. The reaction mixture is treated with 50 ml diethyl ether, and the precipitate is recovered by filtration, then washed with diethyl ether and dried in vacuo. 965 mg (92% of theory) of the target compound are thus obtained

후처리

  1. additionare rapidly added dropwise to this suspension
  2. filtrationthe precipitate is recovered by filtration
  3. washwashed with diethyl ether
  4. customdried in vacuo
  5. custom965 mg (92% of theory) of the target compound are thus obtained

출처 및 근거

ORD 기록
ord-2c0ae19a6c554b7dac355565390b1e09
출처 데이터셋
uspto-grants-2011_12
특허 번호
US08084481B2

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