Hydrochloric Acid → HCID 58011854, compound

Participants

Reaction Steps

0.89 g (3.75 mmol) of 2-(2-fluorobenzoyl)-N-cyclopropylhydrazinecarboxamide from Example 3A are heated under reflux in 3.75 ml 2 N aqueous sodium hydroxide for about 45 hrs. To complete the reaction, a further 5 ml 6 N aqueous sodium hydroxide are added and the mixture heated once more under reflux for 6 hrs. After cooling, it is acidified with 1 N hydrochloric acid with stirring and the reaction mixture extracted three times with ethyl acetate. The combined organic phases are dried over magnesium sulphate and concentrated. 0.74 g (73% of theory) of the target compound are thus obtained, which is further reacted without further purification.

Provenance & Evidence