Ethyl chloroacetate → HCID 58012137, compound

Participants

Reaction Steps

527 mg (4.30 mmol) of ethyl chloroacetate are added to 1.09 g (4.30 mmol) of 5-(4-chlorophenyl)-4-(2-methoxyethyl)-2,4-dihydro-3H-1,2,4-triazol-3-one from Example 49A and 1.19 g (8.59 mmol) of potassium carbonate in 20 ml acetonitrile and the mixture is heated under reflux for 3 hours with stirring. After purification of the resulting crude product by preparative HPLC [Method 9] 810 mg (42% of theory) of the target compound are obtained.

Provenance & Evidence