HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 660863Generated: October 27, 2026
4'-Chloropropiophenone → 2-Bromo-1-(4-chlorophenyl)propan-1-one
https://huagongshe.com/reaction/660863
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4'-Chloropropiophenone | HCID 22697 | — |
| Reactant | Bromine | HCID 24408 | — |
| Catalyst | Hydrogen Bromide | HCID 260 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Bromo-1-(4-chlorophenyl)propan-1-one | HCID 3788219 | — |
Reaction Steps
3000 mg (17.791 mmol) of 1-(4-chlorophenyl)propan-1-one are placed in 15 ml dichloromethane and treated with one drop of hydrobromic acid. The mixture is stirred at 35° C., then 2843 mg (17.791 mmol) of bromine are added dropwise so that the reaction solution decolorizes again after each addition. Three hours after the start of the reaction, the mixture is evaporated to dryness. 4490 mg (96% of theory) of the target compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08084481B2 |
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| Source dataset | uspto-grants-2011_12 |
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| ORD ID | ord-5804ae4831a5411aa350e8d72d680bd0 |
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| Source note | uspto-grants-2011_12 |
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