Ethyl chloroacetate → HCID 58012197, compound

Participants

Reaction Steps

685 mg (3.076 mmol) of 5-(4-chlorophenyl)-1-ethyl-1,3-dihydro-2H-imidazol-2-one from Example 119A are placed in 10 ml acetonitrile, treated with 377 mg (3.076 mmol) of ethyl chloroacetate and 850 mg (6.152 mmol) of potassium carbonate and stirred under reflux overnight. The reaction mixture is evaporated, the residue is partitioned between dichloromethane and water, the organic phase is separated, and this is dried over sodium sulphate and again concentrated. The crude product is purified by flash chromatography on silica gel (eluent: first dichloromethane, then dichloromethane/methanol 100:1→50:1) and thus yields 226 mg (26% of theory) of the target compound.

Provenance & Evidence