Hydrochloric Acid → [4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetic acid

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Reaction Steps

502 mg (1.28 mmol) of ethyl[4-(4-bromophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetate from Example 124A are placed in 0.94 ml methanol, treated with 0.34 ml 20% aqueous potassium hydroxide and stirred overnight at room temperature. It is adjusted to pH 3 with 1 N hydrochloric acid, the resulting precipitate recovered by filtration, and the product washed with water and dried in vacuo. 369 mg (80% of theory) of the target compound, which is reacted without further purification, are thus obtained.

Provenance & Evidence