Hydrochloric Acid → HCID 58012116, compound

Participants

Reaction Steps

6.3 g (19.2 mmol) of the compound from Example 151A are heated overnight under reflux in 38.4 ml of 4 N aqueous sodium hydroxide. After cooling to RT, the mixture is diluted with water and adjusted to pH 10 by addition of 1 N hydrochloric acid. The product is extracted several times with ethyl acetate. The combined organic phases are washed with water to a neutral pH value, then washed with saturated sodium chloride solution and dried over sodium sulphate. After filtration, the solvent is removed on the rotary evaporator. 4.07 g (68% of theory) of the title compound are obtained.

Provenance & Evidence