反应详情

A solution of 3.41 g (12.27 mmol) of the compound from Example 231A in 14 ml methanol/water (7:3) is added dropwise to a solution of 995 mg (12.27 mmol) of potassium isocyanate in 11 ml methanol/water (7:3). This is stirred for 1 hr at RT. The thick suspension is diluted with 7.4 ml water and 39 ml methanol to facilitate stirring, then heated under reflux for 1 hr and then left to stand overnight at RT. After cooling to 0° C., the precipitate is filtered off, washed with ice-cold water and dried overnight in the drying cabinet at 60° C. 2.84 g (76% of theory) of the title compound are obtained.

1. stirringto facilitate stirring
2. temperatureheated
3. temperatureunder reflux for 1 hr
4. waitleft
5. waitto stand overnight at RT
6. temperatureAfter cooling to 0° C.
7. filtrationthe precipitate is filtered off
8. washwashed with ice-cold water
9. customdried overnight in the drying cabinet at 60° C