Water → HCID 58012101, compound

Participants

Reaction Steps

40.0 mg (0.144 mmol) of [4-cyclopropyl-3-(2-fluorophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-yl]-acetic acid from Example 92A, 19.2 mg (0.159 mmol) of 2-phenylethylamine and 23.4 mg (0.173 mmol) of HOBt are placed in 2 ml of dimethylformamide and treated with 36.0 mg (0.188 mmol) of EDC hydrochloride. This is stirred overnight at room temperature, then diluted with 10 ml of water and extracted with ethyl acetate. After evaporation of the organic phase, the crude product is purified by preparative HPLC [Method 9]. 32.0 mg (58% of theory) of the target compound are thus obtained.

Provenance & Evidence