1-Hydroxybenzotriazole → HCID 58011763, compound

Participants

Reaction Steps

30.0 mg (0.102 mmol) of [3-(3-chlorophenyl)-4-cyclopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetic acid from Example 104A, 19.7 mg (0.112 mmol) of 3-trifluoromethylbenzylamine and 16.6 mg (0.123 mmol) of HOBt are placed in 0.75 ml of dimethylformamide and treated with 25.5 mg (0.133 mmol) of EDC hydrochloride. This is stirred overnight at room temperature and the reaction solution is purified directly by preparative HPLC [Method 9]. 20 mg (43% of theory) of the target compound are thus obtained.

Provenance & Evidence