Acetic Acid → HCID 58011709, compound

Participants

Reaction Steps

50.0 mg (0.171 mmol) of 4-(4-chlorophenyl)-3-cyclopropyl-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-acetic acid from Example 130A, 32.9 mg (0.188 mmol) of 3-trifluoromethylbenzylamine and 27.7 mg (0.205 mmol) of HOBt are placed in 1.5 ml of dimethylformamide and treated with 42.6 mg (0.222 mmol) of EDC hydrochloride. This is stirred overnight at room temperature, then stirred with 19 ml of water and the resulting precipitate recovered by filtration. The crude product is washed with water and dried in vacuo. 65 mg (85% of theory) of the target compound are thus obtained.

Provenance & Evidence