1-(Isoquinolin-1-yl)ethan-1-amine → 2-[3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-N-[1-(isoquinoline-1-yl)ethyl]-acetamide

Participants

Role	Name	HCID	Charge
Reactant	1-(Isoquinolin-1-yl)ethan-1-amine	HCID 12243109	—
Reactant	[3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-acetic acid	HCID 58012119	—
Product	2-[3-(4-chlorophenyl)-4-(2-fluorobenzyl)-5-oxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]-N-[1-(isoquinoline-1-yl)ethyl]-acetamide	HCID 58012191	70%

Reaction Steps

The title compound is prepared analogously to Example 264 from the carboxylic acid from Example 156A (40 mg, 0.11 mmol) and 26.7 mg (0.16 mmol) of 1-isoquinolin-1-ylethylamine [preparation: see Chem. Ber. 108, 3771-3778 (1975)]. Yield: 70% of theory

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08084481B2
Source dataset	uspto-grants-2011_12
ORD ID	ord-1c0e6de8fbf94a56bfa5ddc9cb8f847d
Source note	uspto-grants-2011_12