Toluene → HCID 58012109, compound

Participants

Reaction Steps

119 mg (0.23 mmol) of tert.-butyl[3-(4-chlorophenyl)-5-oxo-1-(2-oxo-2-{[3-(trifluoromethyl)-benzyl]amino}ethyl)-1,5-dihydro-4H-1,2,4-triazol-4-yl]-acetate from Example 420 are dissolved in 9 ml of dichloromethane and treated with 3 ml of trifluoroacetic acid. This is stirred for 24 hrs at RT. The reaction mixture is then treated with 10 ml of toluene and concentrated under reduced pressure. A further 10 ml of toluene are added, and the mixture again evaporated. This procedure is repeated once again. The crude product is then freed of solvent residues under high vacuum. 110 mg (quantitative) of the target compound are thus obtained.

Provenance & Evidence