Lithium Hydroxide → HCID 58011944, compound

Participants

Reaction Steps

237 mg (0.45 mmol) of ethyl {3-(4-chlorophenyl)-1-[2-({1-methyl-1-[3-(trifluoromethyl)phenyl]-ethyl}amino)-2-oxoethyl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}-acetate from Example 429 are dissolved in 3 ml of methanol and treated with 0.9 ml of 1 N aqueous lithium hydroxide solution. This is stirred for 24 hrs at RT. The reaction mixture is then concentrated under reduced pressure. 5 ml of water are added, and the mixture is acidified with 1 ml of 1 N hydrochloric acid and extracted twice with 10 ml of ethyl acetate each time. The combined organic phases are dried over sodium sulphate, filtered and concentrated in vacuo. The product that remains is freed from solvent residues under high vacuum. 220 mg (97% of theory) of the target compound are thus obtained.

Provenance & Evidence